The Ford E-150 cargo vans or passenger wagons are built on a rugged platform and offer large interiors with vast cargo capacities.

The Ford E-150 comes with a standard 225-hp 4.6-liter Triton V8 with an optional 255-hp 5.4-liter Triton V8. Both engines are mated to a four-speed automatic transmission. Standard features include four-wheel anti-lock disc brakes, underbody full-size spare, air conditioning, tilt steering wheel and variable intermittent wipers. The cargo van is available in regular or extended length version. The regular length van offers both a commercial and a recreational trim while the extended version offers the commercial trim only. The recreational trim is nicely primed for modifications to suit the buyer's needs. The E-150 passenger wagon comes in the rugged XL trim or the well equipped XLT trim which can carry up to eight passengers. Available equipment on the E-150 includes satellite radio, SYNC, a heavy-duty trailer towing package, an integrated trailer brake controller, navigation system and a selection of Ford Work Solution options.

For 2012, every trim on the E-Series cargo van or passenger wagon has an auxiliary audio input jack as standard equipment.<